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Sarah Spiegel Selected Research

Obesity

12/2023Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis.
1/2023ORMDL in metabolic health and disease.
1/2021Sphingolipids in metabolic disease: The good, the bad, and the unknown.
1/2018Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.
10/2017Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology.

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Sarah Spiegel Research Topics

Disease

56Neoplasms (Cancer)
09/2023 - 11/2002
30Inflammation (Inflammations)
12/2023 - 06/2003
18Breast Neoplasms (Breast Cancer)
01/2023 - 11/2002
13Multiple Sclerosis
10/2020 - 02/2007
11Asthma (Bronchial Asthma)
01/2023 - 09/2002
9Neoplasm Metastasis (Metastasis)
01/2023 - 02/2012
8Melanoma (Melanoma, Malignant)
01/2016 - 01/2005
6Fibrosis (Cirrhosis)
12/2023 - 11/2016
6Glioma (Gliomas)
05/2015 - 04/2002
6Leukemia
08/2008 - 04/2004
5Obesity
12/2023 - 10/2017
5Non-alcoholic Fatty Liver Disease
01/2022 - 10/2017
5Neuralgia (Stump Neuralgia)
11/2020 - 01/2018
5Ovarian Neoplasms (Ovarian Cancer)
01/2019 - 10/2003
5Hypersensitivity (Allergy)
04/2015 - 09/2002
5Glioblastoma (Glioblastoma Multiforme)
02/2010 - 02/2008
4Chronic Pain
11/2020 - 01/2019
4Infections
08/2020 - 03/2010
4Pathologic Processes
12/2016 - 01/2004
4Carcinogenesis
01/2016 - 11/2002
4Anaphylaxis (Anaphylactic Shock)
05/2012 - 09/2007
3Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)
05/2024 - 12/2013
3Alcoholic Fatty Liver
12/2023 - 01/2022
3Pain (Aches)
11/2020 - 09/2017
3Triple Negative Breast Neoplasms
01/2020 - 01/2018
3Autoimmune Diseases (Autoimmune Disease)
01/2019 - 11/2007
3Colitis
01/2016 - 01/2014
3Ulcerative Colitis
01/2016 - 01/2013
3Colonic Neoplasms (Colon Cancer)
01/2014 - 08/2008
3Carcinoma (Carcinomatosis)
08/2010 - 11/2007
3Starvation
02/2007 - 06/2005
2Liver Cirrhosis (Hepatic Cirrhosis)
12/2023 - 10/2017
2Insulin Resistance
12/2023 - 01/2019
2Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2022 - 10/2017
2Mitochondrial Diseases (Mitochondrial Disease)
01/2022 - 03/2005
2Hepatocellular Carcinoma (Hepatoma)
01/2022 - 01/2020
2Neuroinflammatory Diseases
12/2021 - 12/2015
2Hyperalgesia
10/2020 - 01/2020
2Lung Neoplasms (Lung Cancer)
01/2020 - 01/2019
2Neurodegenerative Diseases (Neurodegenerative Disease)
01/2017 - 04/2007
2Pancreatic Neoplasms (Pancreatic Cancer)
10/2016 - 08/2010
2Respiratory Hypersensitivity
10/2015 - 02/2013
2Fistula
04/2015 - 01/2012

Drug/Important Bio-Agent (IBA)

59sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
12/2023 - 09/2002
47SphingolipidsIBA
05/2024 - 04/2002
36sphingosine kinaseIBA
01/2023 - 04/2002
26CeramidesIBA
12/2023 - 04/2002
24LipidsIBA
01/2023 - 03/2006
24Fingolimod Hydrochloride (FTY720)FDA Link
01/2022 - 12/2004
14EnzymesIBA
12/2021 - 04/2002
12Proteins (Proteins, Gene)FDA Link
01/2022 - 02/2008
12Phosphotransferases (Kinase)IBA
01/2021 - 06/2008
12CytokinesIBA
08/2020 - 02/2008
12SphingosineIBA
01/2018 - 11/2002
11Sphingosine-1-Phosphate ReceptorsIBA
01/2022 - 06/2005
6Biomarkers (Surrogate Marker)IBA
05/2021 - 08/2012
6Epidermal Growth Factor (EGF)IBA
08/2008 - 06/2005
5Messenger RNA (mRNA)IBA
01/2022 - 08/2008
5ProdrugsIBA
01/2020 - 12/2004
5LigandsIBA
12/2018 - 04/2007
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2016 - 04/2002
5Interleukin-1 (Interleukin 1)IBA
01/2016 - 09/2008
5InterleukinsIBA
03/2010 - 06/2003
4Protein Isoforms (Isoforms)IBA
01/2023 - 10/2015
4Opioid Analgesics (Opioids)IBA
11/2020 - 01/2019
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2019 - 11/2009
4Interleukin-6 (Interleukin 6)IBA
01/2018 - 04/2008
4IsoenzymesIBA
01/2018 - 09/2009
4AntigensIBA
04/2015 - 09/2002
4Histone Deacetylase InhibitorsIBA
12/2013 - 04/2004
4G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
06/2011 - 10/2003
3SugarsIBA
12/2023 - 10/2017
3Estrogens (Estrogen)FDA Link
01/2022 - 11/2002
3Small Interfering RNA (siRNA)IBA
01/2019 - 10/2006
3Pemetrexed (MTA)FDA Link
01/2019 - 07/2012
3Estrogen ReceptorsIBA
12/2018 - 01/2016
3Phosphates (Orthophosphate)IBA
01/2016 - 06/2005
3ChemokinesIBA
12/2015 - 02/2013
3Immunosuppressive Agents (Immunosuppressants)IBA
10/2015 - 12/2004
3JTE 013IBA
04/2015 - 03/2010
3Immunoglobulin E (IgE)IBA
02/2013 - 06/2003
3Drug CombinationsIBA
07/2012 - 10/2008
3Sorafenib (BAY 43-9006)FDA Link
07/2012 - 10/2008
3lysophosphatidic acidIBA
09/2010 - 06/2005
3VorinostatFDA Link
08/2010 - 03/2005
2Glucose (Dextrose)FDA LinkGeneric
12/2023 - 10/2017
2Serine C-PalmitoyltransferaseIBA
01/2023 - 01/2019
2CannabinoidsIBA
12/2021 - 08/2009
2Non-Narcotic Analgesics (Analgesics, Non Narcotic)IBA
11/2020 - 01/2019
2Morphine (MS Contin)FDA LinkGeneric
10/2020 - 01/2020
2Fatty Acid Synthases (Fatty Acid Synthase)IBA
02/2020 - 01/2019
2CholesterolIBA
01/2020 - 01/2017
2Bortezomib (Velcade)FDA Link
01/2020 - 01/2018
2Adenosine Triphosphate (ATP)IBA
01/2018 - 01/2016
2Histone Deacetylases (Histone Deacetylase)IBA
01/2017 - 04/2004
2Dextrans (Dextran)FDA Link
01/2016 - 12/2015
2sodium sulfate (sodium bisulfate)FDA LinkGeneric
01/2016 - 12/2015

Therapy/Procedure

17Therapeutics
11/2020 - 01/2005
5Drug Therapy (Chemotherapy)
01/2020 - 01/2005
2Oral Administration
01/2016 - 01/2013